OUR INGREDIENTS
SCIENCE-BAKED AND FORMULATED TO WORK
Ensuring Excellence at Every Step
Our rigorous quality control process includes:
- Sourcing from trusted suppliers
- Testing for heavy metals and contaminants
- Manufacturing in FDA-registered facilities
- Adhering to Current Good Manufacturing Practices
OUR INGREDIENTS
VITAMIN B6
Found in: chickpeas, potatoes (with skin), avocados, spinach, bananas and many other foods.
Benefits: Supports healthy kidney function by aiding in the metabolism of waste products.*
Source: Pyridoxine HCl
Origin: Germany
MAGNESIUM CITRATE
Found in: Magnesium is found naturally in many foods like leafy green vegetables (spinach, kale), nuts (almonds, cashews), seeds (pumpkin, chia), legumes (black beans, chickpeas), and whole grains.
Citric Acid is a naturally occurring organic acid abundant in citrus fruits like lemons, limes, and oranges. Smaller amounts are found in other fruits and vegetables.
Benefits: Supports healthy kidney function by promoting mineral balance and waste processing.*
Origin: United States
L-GLUTAMINE
Found in: Naturally produced by the body; also found in many plant-based foods like tofu, tempeh, white rice, corn, legumes (beans, lentils, chickpeas), nuts and seeds (almonds, pumpkin seeds), and leafy green vegetables (spinach, cabbage, parsley).
Benefits: Supports healthy kidney function by aiding in acid-base balance and supporting cellular integrity.*
Source: Fermentation of glucose from corn syrup
Origin: United States
CORN SILK
Found in: The inside of the corn husk, specifically the Stigma maydis, which are the fine, silky threads attached to each developing kernel.
Benefits: Traditionally used to support urinary tract health, may help promote healthy fluid balance and soothe the kidneys and bladder.*
Origin: Mexico
D-MANNOSE
Found in: The inside of the corn husk, specifically the Stigma maydis, which are the fine, silky threads attached to each developing kernel.
Benefits: Traditionally used to support urinary tract health, may help promote healthy fluid balance and soothe the kidneys and bladder. *
Source: Our glucose is derived from non-GMO Corn Starch and is transformed by epimerization.
Origin: China
SCROLL EACH INGREDIENT TO LEARN MORE
RESEARCH BACKED INGREDIENTS
- Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. 1999 Apr;10(4):840-5. doi: 10.1681/ASN.V104840. PMID: 10203369.
- Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemodialysis and human recombinant erythropoietin. Nephrol Dial Transplant. Okada H, Moriwaki K, Kanno Y, Sugahara S, Nakamoto H, Yoshizawa M, Suzuki H. 2000 Sep;15(9):1410-3. doi: 10.1093/ndt/15.9.1410. PMID: 10978399.
- Vitamin B6 Metabolism in Chronic Kidney Disease. Nephron Clin Pract. Suliman ME, Stenvinkel P, Barany P, et al.2010;114(1):c38-46. doi: 10.1159/000243866.
- Effect of B-Vitamin Therapy on Progression of Diabetic Nephropathy: A Randomized Controlled Trial. Majumder S, Advani A, Alexander M, et al. JAMA. 2010 Apr 28;303(16):1603-9. doi: 10.1001/jama.2010.491. PMID: 20424256.
- Metabolism of vitamin B6 and its requirement in chronic renal failure. Nephron. Suliman ME, Stenvinkel P, Barany P, et al.1997;77(1):37-43. doi: 10.1159/000190160. PMID: 9350682.
- Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial. Taheri M, Jalali S, Borumandnia N, Tavasoli S, Basiri A, Taheri F. Magnes Res. 2024 Jul 1;37(1):12-21. doi: 10.1684/mrh.2024.0524. PMID: 39077820.
- Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss. Am J Kidney Dis. Ruml LA, Pak CY. 1999 Jul;34(1):107-13. doi: 10.1016/s0272-6386(99)70115-0. PMID: 10401023.
- The emerging role of magnesium in CKD. Clin Exp Nephrol. Sakaguchi Y. 2022 May;26(5):379-384. doi: 10.1007/s10157-022-02182-4. Epub 2022 Jan 25. PMID: 35076791; PMCID: PMC9012765.
- The association between serum magnesium and chronic kidney disease in Chinese adults: a cross-sectional study. BMC Public Health. Xie JZ, Huang Y, Zheng XF, Feng R, Li XY, Zheng ZG, Jiang BJ, Du S, Chen HG, Xu Y. 2024 Jan 15;24(1):187. doi: 10.1186/s12889-023-17615-2. PMID: 38225595; PMCID: PMC10790542.
- Interventions To Attenuate Vascular Calcification Progression in Chronic Kidney Disease: A Systematic Review of Clinical Trials. Xu C, Smith ER, Tiong MK, Ruderman I, Toussaint ND. J Am Soc Nephrol. 2022 May;33(5):1011-1032. doi: 10.1681/ASN.2021101327. Epub 2022 Mar 1. PMID: 35232774; PMCID: PMC9063901.
- L-glutamine therapy reduces sickle cell-related complications in pediatric and adult patients with sickle cell disease: a phase 3 randomized trial. Blood. Morris CR, Vichinsky EP, van Warmerdam J, et al. 2017;130(Supplement 1):542.
- Real-world observational study on the long-term effect of L-glutamine on renal function in sickle cell disease. Al-Mashdali AF, Alkhateeb A, Alshurafa A, Alkhateeb H, Alshurafa S, Alshurafa S.Front Med (Lausanne). 2023;10:1243870. doi: 10.3389/fmed.2023.1243870. PMID: 38209595.
- The effect of glutamine administration on urinary ammonium excretion in men. J Clin Invest. Halperin ML, Goldstein MB, Kamel KS, Stinebaugh BJ, Sakhaee K, Narins RG. 1979;64(3):760-768. doi: 10.1172/JCI109511. PMID: 380527.
- Glutamine administration ameliorates sepsis-induced kidney injury by downregulating HMGB-1 and related pathways. Wang Y, et al. Am J Physiol Renal Physiol. 2012;302(1):F40-F49. doi:10.1152/ajprenal.00299.2011. PMID: 21921023.
- Glutamine prevents apoptosis of human kidney 2 cells by inducing heme oxygenase-1 through p38 MAPK-dependent mechanism. Nephrol Dial Transplant. Niihata K, Kawasaki T, Kudo A, et al. 2010;25(3):674-684. doi: 10.1093/ndt/gfp480. PMID: 19744952.
- Metabolite Profiling and Nephroprotective Potential of the Zea mays L. in Diclofenac-Induced Nephrotoxicity. Wang Y, et al. ACS Omega. 2022;7(42):37240-37256. doi:10.1021/acsomega.2c04396.
- Corn Silk Polysaccharide Reduces the Risk of Kidney Stone Formation by Reducing Oxidative Stress and Inhibiting COM Crystal Adhesion. Zou GJ, et al. ACS Omega. 2024;9(17):18985-18996. doi:10.1021/acsomega.4c00110.
- Antiurolithiasis Activities of Zea mays Extract and Its Mechanism as Anti-Calcium Oxalate. Front Med (Lausanne). Al-Mashdali AF, et al. 2023;10:1243870. doi:10.3389/fmed.2023.1243870.
- Protective Effect of Corn Silk on Kidney and Liver Functions of Rats. Naeem MM. Bull Natl Nutr Inst Egypt. 2022;60:122-135. doi:10.21608/bnni.2022.273591.
- Corn silk aqueous extract ameliorates cisplatin-induced nephrotoxicity in rats via modulation of oxidative stress and inflammation. Elsawy MM, Abdelrahman RS, Wahdan SA, et al. Biomed Pharmacother. 2022;151:113145. doi:10.1016/j.biopha.2022.113145.
- Systematic review and meta-analysis showing D-mannose protective for recurrent UTIs compared to placebo, with effectiveness similar to antibiotics. Stacy M Lenger, Megan S Bradley, Debbie A Thomas, Marnie H Bertolet, Jerry L Lowder, Siobhan Sutcliffe. 2020 Aug;223(2):265.e1-265.e13. doi: 10.1016/j.ajog.2020.05.048. Epub 2020 Jun 1. PMID: 32497610
- Systematic review describing D-mannose's mechanism blocking E. coli adhesion and safety, showing lowered risk of recurrent UTIs. Florian Wagenlehner, Horst Lorenz, Oda Ewald, Peter Gerke. 2022 Feb 25;11(3):314. doi: 10.3390/antibiotics11030314. PMID: 35326777
- Randomized double-blind, placebo-controlled trial in India demonstrating the effectiveness and safety of a D-mannose-based supplement for uncomplicated E. coli UTIs. Stefano Salvatore, Alessandro Ferdinando Ruffolo, Guglielmo Stabile, Arianna Casiraghi, Gabriella Zito, Francesco De Seta. 2023 Jul;9(4):654-659. doi: 10.1016/j.euf.2022.12.013. Epub 2023 Jan 6. PMID: 36621376
- Network meta-analysis showing significant reduction of UTI incidence with D-mannose among nonantibiotic prophylaxis options. Zeyu Han, Xianyanling Yi, Jin Li, Dazhou Liao, Jianzhong Ai. 2025 Apr;53(2):535-546. doi: 10.1007/s15010-024-02357-z. Epub 2024 Aug 2. PMID: 39095666
- Updated systematic review and meta-analysis in adult women on D-mannose for recurrent UTI prophylaxis. Mrinal Murali Krishna, N/A, MBBS , Meghna Joseph, MBBS , Chidubem Ezenna, MD , Lal Sadasivan Sreemathy, MBBS, MPH, MBA, PhD. 29 January 2025. https://academic.oup.com/ofid/article/12/Supplement_1/ofae631.1737/7986981
OUR PROMISE TO YOU
At Axobotanica, we are dedicated to providing you with the highest quality supplements that support your health and wellness journey. Our commitment ensures that you can trust what you put into your body. We believe that informed choices lead to better health outcomes, and we strive to empower you with knowledge about our ingredients and their benefits.
Our focus will always remain on delivering natural, science-backed solutions for wellness.
